good video w some caveats: though sir2 overexpression extends replicative lifespan, this only benefits 1 in 5 million yeast cells sir2 opposes lifespan in yeast & in flies--this means that the sir2 target itself doesn't make sense as something we're trying to increase in aging x.com/BradStanfieldM…
The David Sinclair (@davidasinclair) $720,000,000 Resveratrol Train Wreck Video shoutouts: - Prof. Matt Kaeberlein (@mkaeberlein) - Prof. Brian Kennedy (@BKennedy_aging) - Dr. Peter Attia (@PeterAttiaMD) - Prof. Richard Miller - Prof. Jeffery Flier (@jflier) pic.twitter.com/vLKyvkWJCq
PS. My position is that all current supplements/diets will only give you marginal benefits at best, that is perhaps 1-2 years in additional life expectancy all else equal, since this is all mostly genes. I don't think it's a good idea to devote much time to exhaustively… twitter.com/i/web/status/1…
This looks useful - someone read most of the major longevity books and compiled a list of recs. reddit.com/r/PeterAttia/c… pic.twitter.com/05jeDebLre
Why do I drink matcha instead of coffee? 🍵 A molecule in matcha, may fight cancer and aging. In mice, ECGC lowers death risk by 47% & extends median lifespan by 25% 😮 I know we’re not mice but I’d drink it even if it did nothing. Thanks for the tip @chefserenapoon 👏 pic.twitter.com/toZ7MmfbYn
I don’t know that I’ve seen any other non-fiction book on @goodreads with over 4.4 stars at > 40K reviews. If you’re going to read one health book for the New Year, make it this one pic.twitter.com/eiRdKb5nS4
Stem cell and PRP for $800. This would be $10,000+ in America. 7m cells for shoulder. Have met people beating Lyme, diabetes, and all sorts of knee/ shoulder injuries. Insane and incredible, not sure how to describe the experience and stories I've heard so far. pic.twitter.com/z4iDeaclUU
Lifespan vs. Healthspan vs. Joyspan; Our Quantified Trade-offs Ahead David Sinclair originally introduced many of us to the concepts of lifespan (how long you live) and healthspan (how long you are healthy) that distinguish between how long you technically live and how long you… twitter.com/i/web/status/1…
2 years of vigorous exercise in 50-year-olds was able to reverse the aging of their hearts by 20 years! Effectively making the heart look more like a 30-year-old's The power of exercise.... Astonishing, really pic.twitter.com/iP84lGGiKH
Fascinating new preprint on bioRxiv tackles a whale of a question: Whales are huge. So why don’t they get a ton of cancers? biorxiv.org/content/10.110… pic.twitter.com/V3zlGQ4SPf
There are two camps. Those who read scientific papers & understand that resveratrol 🍷 is a proven SIRT1 activator that works in clinical trials…and those who don’t 🙉 1/9… academic.oup.com/proteincell/ar… pic.twitter.com/4o6I4LbXYa
Cytomegalovirus hides in 80-100 percent of us. In middle age, zombie-like senescent cells accumulate & promote aging, but somehow stop accumulating late in life. New paper looking at skin says it’s because the virus reactivates as we age, flagging old cells for clearance by the… twitter.com/i/web/status/1… pic.twitter.com/joiYAP3dcF
A thread on ageing as a software design flaw 🧵 The hypothesis is that most (but not all) ageing changes are not a result of a build-up of molecular damage but are rather a product of regulated processes. Figures from the paper: genomebiology.biomedcentral.com/articles/10.11… pic.twitter.com/k63om4841I
If you combined Tik Tok’s algorithm with YouTube’s creator program and hired 1k teachers for each subject, you’d have an insanely informative, addictive, and lucrative (for the teachers) way to increase education levels across the country and level the playing field.
What if there’s no such thing as “aging”? sciencedirect.com/science/articl… pic.twitter.com/h3WFdX2clS
The type 2 diabetes drug metformin is finally shown to slow aging! Aging needs to be called a “disease” so drugs like metformin can be prescribed before we get sick @US_FDA frontiersin.org/articles/10.33…
$200 for a full genome @illumina? Now anyone can get one. I miss the days when they were $2,000,000,000
Age of skin cells reversed by 30 years Scientists in the UK have rejuvenated a 53-year-old woman's skin cells, so they are the equivalent of a 23-year-old's. ▶️ Read more: futuretimeline.net/blog/2022/04/8… #aging #ageing #longevity #skincare #skin #healthnews @mfoundation @BrentNally pic.twitter.com/2fEI2iMHlq
This is a crazy study. The more you walk, the longer you live. pic.twitter.com/oQYyl0zfmO
Now in production: Rejuvant®, an alpha-ketoglutarate based formulation, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA Methylation test twitter.com/Blagosklonny/s…
This is Jonathan. He is a tortoise. He was born in 1832 making him the oldest living animal on earth at 189 years of age. He was born when Andrew Jackson was President and Abraham Lincoln was 23 years old. Credit: St. Helena Government pic.twitter.com/HY96QJJYql
- Aging is a disease
Boosting levels of the NAD-sensitive enzyme SIRT6 extends the lifespan of mice by a whopping 30%!! From the lab of Haim Cohen @BarIlanU, who, in 1999, bravely joined me at Harvard to tackle aging, before my lab had even been built! #fitness nature.com/articles/s4146…
Now, we have no idea if we are about to have a heart attack or grow a tumor. Those days will soon be over
it's pretty crazy that we might have actually have found a safe drug that targets obesity - semaglutide This study looks at whether stopping semaglutide in the middle would stop the weight loss, and it did (suggesting it's really the drug doing the work) jamanetwork.com/journals/jama/… pic.twitter.com/hHphT4mmxs
Everybody makes fun of the people who will go into a clearly haunted house or an obvious murder basement but my least favorite "never saw a horror movie" real life trope is people who think eugenics "would be a good or even great thing, if done for the right reasons".